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The accumulation of Fe2+ and Fe3+ signifies an iron overload due to excessive iron build-up, and this is a key factor in ferroptosis (15)

The discipline of traditional Chinese medicine constitution divides people into nine subgroups: balanced, relatively healthy constitution and eight unbalanced constitutions (qi-deficient, yang-deficient, yin-deficient, phlegm-dampness, dampness-heat, blood stasis, qi-stagnation, and inherited special constitution)

J Mater SciMater Med 31:97 Maierhofer A, Flunkert J, Oshima J, Martin GM, Haaf T, Horvath S (2017) Accelerated epigenetic aging in Werner syndrome