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However, their primary mechanism of action involves inhibition of neuronal signal transmission at the peripheral nerve terminals, with limited direct effects on skin barrier restoration and local immune modulation

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Common symptoms of insomnia include: [1][2][3] Struggling to fall asleep at night Regularly waking up in the night Waking very early in the morning unable to fall back to sleep Feeling very tired throughout the day Changes in mood, including irritability, low mood, and anxiety Difficulty concentrating Impaired social functioning Poor performance at work Physical pains, such as headaches and stomach pain Is insomnia dangerous