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Additionally, rhamnetin disrupts the cleavage of the Notch-1 receptor by gamma-secretase, preventing the release of the Notch intracellular domain (NICD)

Comparator (C), gene deletion and wild type

doi: 10.1016/j.bcp.2025.116797 [DOI] [PubMed] [Google Scholar] 171.Santn-Mrquez R, Alarcn-Aguilar A, Lpez-Diazguerrero NE, Chondrogianni N, Knigsberg M

Dysbiosis-induced increased intestinal permeability allows the translocation of bacterial endotoxins, notably LPS, into the systemic circulation, triggering inflammatory cascades that compromise thyroid tissue integrity and hormone synthesis