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Cls treatment significantly reduced ethanol-induced upregulation of the pro-inflammatory markers (IL-1, IL-6, TNF-, and NF-B), MDA (a marker of lipid peroxidation), and caspase-3 and cleaved caspase-3 (apoptotic markers)

J Mol Biol 370(3):512529

Suyin Detoxification Granule alleviates trimethylamine N-oxide-induced tubular ferroptosis and renal fibrosis to prevent chronic kidney disease progression

Nevertheless, while animals represent a tool to study NAFLD and NASH, it is unlikely that any single animal model will reflect all aspects of human NASH and researchers must critically select the model(s) best suited for the subject of investigation