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Among the most abundant alkaloids found in this plant, there is a mixture of pentacyclic oxindole stereoisomers that differ in configuration at chiral centres in the positions 3, 7, 15, 19 and 20 (Figure 2A)

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This interaction supports coordinated regulation of energy metabolism, oxidative homeostasis, and membrane integrity through a division of labor in fatty acid -oxidation, balanced ROS production and scavenging, and membrane lipid synthesis and transport, including ether phospholipids

NMR-Based Serum Metabolomics Reveals Reprogramming of Lipid Dysregulation Following Cyclophosphamide-Based Induction Therapy in Lupus Nephritis