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Bu, sitokin ve byme faktr retiminden ve ayrca hcre d matris (kollajen) oluumundan sorumlu genlerin ekspresyonunu artrarak, barsak anastomozu iyilemesi ve geri dn ile birlikte, ileri ve kt kontrol edilen irritabl barsak hastal gibi ciddi ekilde bozulmu koullarda bile meydana gelir

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