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This mechanistically supports the use of such vitamin antioxidant combinations for DR [44, 50]

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Although primarily focused on ischemiareperfusion injury, the studys findings imply that excessive 4-HNE accumulation under high-glucose and high-lipid conditions may likewise initiate aberrant cardiomyocyte death, contributing to cell loss in DCM

Unfortunately, many biosensors currently in use contain FPs that might be unsuitable for highly oxidising or acidic compartments present in some organelles or the apoplasm, although changing the FPs may help address this (Erard & Guiot, Reference Erard and Guiot2015)