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Experimental evidence indicates that M1 treatment improves cardiac function in HF models and mitigates tau pathology in AD mice

doi: 10.1016/j.cmet.2014.10.005

Administration & Dosing Protocol Subcutaneous Injection (Standard): Loading: 10 mg/week (5 mg 2x, Mon/Thu)

Using the UniProt annotation on protein localization, 45% of both the human and mouse S-palmitoylation hits (679 and 974 for proteins respectively) were annotated as membrane proteins, 30% as cytosolic (445 and 723 proteins respectively) (Figure 5D)