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Abrogation of cisplatin-induced nephrotoxicity in mice by alpha lipoic acid through ameliorating oxidative stress and enhancing gene expression of antioxidant enzymes

[13,14,15] However, clinical outcomes of actively targeted therapies remain unsatisfactory against solid tumors, and the clinical translation of nanomedicine is progressing slowly

To further study the role of NADPH consumption in the H 2 O 2 -induced death of SLC7A11-high cells, we examined whether increasing NADPH consumption can sensitize SLC7A11-low cells to H 2 O 2 -induced cell death