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However, in non-human primates, intranasal delivery of mRNA COVID-19 vaccines failed to enhance mucosal immunity, while adenovirus-based vaccine achieved robust immune response, indicating formulation improvements are necessary for the mucosal delivery of mRNA vaccines [224, 225]

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The 3R allele for this variant is associated with a 24 fold increase in expression of the TYMS enzyme, as a result of the effect of this variant on the translation efficiency of TYMS