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5.2 Limitations of conventional topical flavonoid delivery Although certain flavonoids such as naringenin and flavanone exhibit enhanced skin permeability under inflamed or barrier-compromised conditions, their transdermal absorption remains limited in intact skin, often necessitating the use of penetration enhancers to achieve therapeutic depth (Wang et al., 2024)

The dermal extracellular matrix (ECM) also exhibits structural and functional changes in intrinsically and extrinsically aged skin

This is especially helpful if your body has trouble absorbing B12 from food or supplements

You start low and increase gradually