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The estimand concept [3] provides a framework to align trial design and objectives to ensure that the estimated treatment effect is relevant to the scientific question(s) of interest

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In one study, people with obesity who received vitamin D supplements in addition to following a weight loss diet plan lost more weight and fat mass than the members of the placebo group, who only followed the diet plan

It is not uncommon to experience slight swelling for a few days following the procedure or tingling/tenderness to the touch for a few weeks following the procedure, but these are mild and temporary in nature