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USA 96 , 715720 (1999)

Alternatively, small interfering RNA could be delivered to targeted sites via nanoparticle-based systems to suppress the expression of DC metabolic genes associated with allergies, thereby controlling the onset and progression of allergic diseases at their source

By lowering the mRNA expression of inflammatory cytokines such as TNF-, IFN-, IL-1, and IL-6, reducing macrophage infiltration, and preventing inflammatory signal transduction, GLPs effectively mitigate chronic inflammation