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Although many recent, successful applications of whole genome sequencing have been reported in establishing the etiology of complex diseases and guiding therapeutic decision-making in neoplastic and nonneoplastic diseases, its use remains challenging and must be carefully evaluated before its clinical implementation as a diagnostic test [92]

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In a recent animal study, remote ischemic limb conditioning (RLC) polarized peripheral monocytes to a CCR2 + pro-inflammatory subset both in vitro and in vivo after MCAO

Excessive ROS further damages mtDNA and membrane structures, ultimately accelerating follicular closure [53]