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In agreement with this, ENDO12 showed increased inhibitory activity in cell-based assays compared to ENDO3 (Fig

It is needed for healthy bones and immune function, and it also plays a significant role in reproductive health

Furthermore, a significant number of individuals with fatigue do not have a confirmed underlying diagnosis

Yet chronic HIF activation, as observed in prolonged anemia or systemic hypoxia, contributes to inflammatory signaling, tissue remodeling, and mitochondrial dysfunction, accelerating cellular senescence and organ aging [39]