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was supported by the New Cornerstone Science Foundation through the XPLORER PRIZE

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SLC25A12, SLC25A13, GOT1, and GOT2 levels increased with aging in the cerebral cortex, hippocampus, and cerebellum, while MDH2 levels increased with aging in the cerebral cortex and hippocampus ( To synthesize one molecule of the 16:0 fatty acid palmitate, 14 NADPH molecules are oxidized, while to synthesize one molecule of cholesterol, 18 to 19 molecules of NADPH are oxidized (Vance and Vance, 1996)