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48 Within 23 days following tooth extraction, a significant influx of inflammatory cells migrates to the defect site, where they merge with vascular buds and immature fibroblasts to form granulation tissue

Furthermore, RIPK1 can form a lethal platform known as complex IIb or ripoptosome with FADD and caspase-8, which is negatively regulated by cIAP1, cIAP2, and X-Linked Inhibitor of Apoptosis Protein (XIAP), and can also activate caspase-8-mediated apoptosis