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Thus, excretion of the drug becomes easier Other phases 2 reactions are: N-methylation O-methylation N-acetylation Sulfate conjugation (sulfation) Glutathione conjugation Conjugation with amino acids Conjugation with ribose or ribose phosphates FACTORS THAT AFFECT THE BIOTRANSFORMATION OF DRUGS Induction or inhibition of microsomal enzymes Genetic differences Age Gender Liver diseases Environmental factors Induction or inhibition of microsomal enzymes Various drugs or environmental factors lead to increases in the activity of these enzymes by increasing the synthesis of microsomal enzymes

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