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(San Diego: Academic Press), 513522

It has been shown that rutin is effective in treating cancer at varying degrees by regulating cellular signaling pathways, such as Wnt/-catenin, p53 independent pathway, PI3K/Akt, JAK/STAT, mitogen-activated protein kinase (MAPK), p53, and NF-B pathway (29)

For instance, venetoclax, the first small-molecule Bcl-2 selective inhibitor, has been approved by the FDA for the treatment of chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML) and some subtypes of lymphoma