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Such approaches enable the synchronized modulation of inflammation, proliferation, and tissue remodeling through bioresponsive physicochemical cues, representing a paradigm shift toward actively participating biomaterials [4]

Accordingly, the administration of Ca 2+ /Mg 2+ prior to oxaliplatin infusion has been evaluated in several clinical trials as a strategy to prevent development of CIPN, although a consistent clinical benefit is unfortunately not apparent (Jordan et al., 2016)

Sonication in a water bath for 10-30 seconds at room temperature can help stubborn lots dissolve without the shear stress of vortexing