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Here, we used a mouse model of chronic cutaneous inflammation elicited by the protozoan pathogen Leishmania mexicana to investigate the function and transcriptional dynamics of skin eosinophils

Tuberculosis 90 , 361366 (2010)

These in vivo and in vitro studies were carried out with mice lacking the nuclear factor erythroid 2-related factor-2 ( Nrf2 ), whose gene product is a redox-sensitive transcription factor that is crucial to the regulation of the antioxidant defense system [54,55]

For disease onset, it has been demonstrated that TREX1 reduction and cfDNA accumulation can be risk factors for the onset of RA in elderly through activating the cGAS signaling cascade, and these characteristics have been observed in elderly RA patients and AIA rats