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These findings suggested that angiopep-2 peptide facilitates APM to actively transport drugs across the BTB and greatly increases their accumulation and retention in the brain tissues for an extended period

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Two doses of Berberine were found to have better protection than a single dose, Berberine administered at 200 mg per kg or two hemi concentrations of 100 also the 200 mg per kg effectively blunted bladder oedema, hemorrhage and nitric oxide metabolite elevation