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Los cambios de la concentracin de GSH en sangre podran dar una medida del stress oxidativo in vivo

Wang M , Rule S, Martin P, Auer R, Kahl BS, Jurczak W, Advani RH, Romaguera JE, Williams ME, Barrientos JC, Chmielowska E, Radford JA, Stilgenbauer S, Dreyling M, Jedrzejczak WW, Johnson P, Spurgeon SE, Li L, Zhang L, Newberry KJ, Ou Z, Cheng N, Fang B, McGreivy J, Clow F, Buggy J, Chang BY, Beaupre DM, Kunkel LA, Goy A, Blum KA

It was approved by the ethics committee of IDI-IRCCS (Rome, Italy)

These results suggest that metformin may serve as a promising therapeutic agent for alleviating OA pain and slowing the progression of OA in MIA-induced mouse model, which is consistent with the results of a previous study 42