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The dual targeting of immunometabolic pathways ( via SGLT-2Is/GLP-1RAs) and epigenetic regulators (e.g., miR-155) represents a paradigm shift in DM therapeutics

The generated pre-microRNAs are exported out of the nucleus through Exportin-5/Ran-GTP and further cleaved by the Dicer RNase, resulting in the formation of mature microRNAs, dsRNA fragments of about 20 base pairs in length, which can participate in the formation of the RISC and engage in the RNAi pathway [26]