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Although it is not possible at this stage to identify the mechanisms at the basis of the upregulation of mitochondrial respiration promoted by the presence of the TDP-43 G376D , it is likely that the increased amount of ATP required by the cells to counteract the effect of the mutation drives the upregulation of mitochondrial respiration

The methodology was flawed due to the employment of a highly subjective visual Taylor scale for pre- and post-treatment evaluation of change in skin hue and tone and lack of mention of statistical tests applied

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Their results are crucial for pharmacodynamics, pharmacokinetic, and toxicological research