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Reactive oxygen species can oxidize cellular GSH, leading to the loss of intracellular redox homeostasis and activation of the apoptotic signaling cascade

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The second DMR is distant from the transcriptional initiation site of the PIGZ gene but partially overlaps with a Histone H3 lysine 27 acetylation (H3K27ac) mark (associated with active enhancer function) in the human immortalized myelogenous leukemia cell line K562