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Presence of various hormone and stress-responsive cis-elements on most of the putative CaGST promoter regions could be directly correlated with the alteration of their transcripts

Results Generation of rod-specific IGF-1R KO mice Some null mutants for the IGF-1R gene die of respiratory failure at birth, and those that do survive exhibit a severe growth deficiency (45% normal size) [24, 25]

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The modifications often lead to cellular dysfunction and may have deleterious consequences