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IGF-1 regulates astrocytic glucose control and CNS glucose metabolism (Hernandez-Garzn et al., IGF-1 and Microglia Microglia act as resident macrophages in the CNS and major mediators of neuroinflammatory responses (Prinz and Priller, Microglial cells are a major source of IGF-1, which is upregulated during the inflammatory process

Mohithraj, K

doi: 10.1016/bs.ircmb.2017.07.007 96

This review summarizes recent advances in the mechanisms, co-regulatory pathways, and interactions of pyroptosis, ferroptosis, and autophagy in SCI and outlines new perspectives on the treatment of SCI ( Figure 1 )