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For non-hematological AEs using multivariate logistic regression analysis, the C/T genotype group of MTHFR_a , high serum RBP level before pemetrexed treatment, high serum B12 level before premedication, and high red blood cell (RBC) count before pemetrexed treatment (Supplementary Table S3(a)) were the crude low-risk factors for G2G4 non-hematological AEs in the first cycle