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The electron transfer from NADH+ and FADH+ to NAD and FAD by complexes 1 and 4 produce O 2 radicals which are then converted into H 2 O 2 enzymatically by the catalytic activity of SOD

Additionally, while unspent funds received for a performance year must be reallocated in the spend plan for the ACO's next performance year as noted at 425.640(e)(3), if an ACO fails to spend a majority of the prepaid shared savings received in a performance year, we may withhold future quarterly payments until the ACO spends the funding already received and reports this spending to CMS through an updated spend plan

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