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Interestingly, transfection of neurons with a cDNA construct, in which the pre-pro-domain of BDNF is fused to the mature part of the neurotrophin-4 (NT-4) redirects this BDNF-NT-4 chimera efficiently into vesicles of the regulated secretory pathway, whereas wildtype NT-4 is predominantly located in vesicles of the constitutive secretory pathway (Brigadski et al

A.NeugroschlJ.SchimmingC.et al (2021)

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