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Once they were out of the stinking forest, they could think

We also conducted a secondary analysis in which statistical inference of nicotine was based on a bioequivalence approach using the following standards: (1) the ratio of geometric least-square means (LSmeans) calculated from the exponential of the difference between the Test and each Reference product for the log-transformed parameter C max must be within the 80%125% bioequivalence range

To determine recent tobacco smoke exposure, the researchers measured the levels of cadmium and nicotine (measured as cotinine) in the subjects systems and categorized them as no exposure, light exposure, heavy exposure and active smoking