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A number of clinically and experimentally utilized chemotherapeutic drugs, including the cytostatic agent BCNU, gold and platinum complexes, and compounds acting at the dimer-interface have already been shown to inhibit TrxR1 effectively 2,3,7

Common injection sites include the abdominal area (at least 2 inches from the navel), thighs, or back of the upper arms

Of note, all the studies undertaken in the OCC included in this meta-analysis used 3 T MRS strength, whereas there was variation in MRS strength across the other brain regions (7 T was used for two MFC studies, with 3 T used for three MFC studies)