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The rationale is to open up some space on the mu receptors, thereby increasing sensitivity to pure opioid agonists

Pak J Med Sci 2013, 29:938942

Thorough decontamination is the most effective step you can take

Zeng Y, Yang K, Wang F, Zhou L, Hu Y, Tang M, Tang M et al (2016) The glucagon like peptide 1 analogue, exendin-4, attenuates oxidative stress-induced retinal cell death in early diabetic rats through promoting Sirt1 and Sirt3 expression