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It usually begins between the ages of 50 and 70 and is slightly more common in men than women, with a male-to-female ratio of about 1.51 (Chi et al., 2013)

Dhupar R, Rice RD, Correa AM, Weston BR, Bhutani MS, Maru DM, Betancourt SL, Rice DC, Swisher SG , Hofstetter WL

Structure, evolution and functional roles of plant glutathione transferases., in Glutathione in plant growth, development, and stress tolerance

J Zhejiang Univ Sci B 16:948956 Jin ZG, Ueba H, Tanimoto T, Lungu AO, Frame MD, Berk BC (2003) Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase