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So, additional investigation is necessary to link these potential associations to konzo pathogenesis, particularly in relation to time of disease onset, as such markers may only be present during early phases of konzo onset when inflammation or neural damage is likely highest

Moreover, hydrochlorothiazide have been shown to diminish insulin secretion from islets of obese mice by reducing Ca 2+ influx rather than altering [Cl ] i , K + or Cl fluxes (Sandstrom et al., 1993)

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