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The EFSA concluded that there wasnt enough data to directly create recommendations for children, and so they used an extrapolation from the adult recommendations based on body size and applied a factor for increased needs due to growth (EFSA, 2015, p

Up-regulation of EGR-1 and cyclin D1 A bit more technical: EGR-1 (Early Growth Response 1) and cyclin D1 are transcription factors, proteins that, in the cells nucleus, determine which genes are switched on