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Navigating life with a complex chronic illness like Long COVID, ME/CFS, dysautonomia, or MCAS requires immense resilience

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doi: 10.3389/fonc.2020.01539 Received 31 May 2020 Accepted 19 July 2020 Published 28 August 2020 Volume 10 - 2020 Edited by Bruno Sainz Jr., Autonomous University of Madrid, Spain Reviewed by Patricia Sancho, University of Zaragoza, Spain

For example, the spacer can be selected from the group consisting of -C1-C10 alkylene- , -C1-C10 heteroalkylene-, -C3-C8 carbocyclo-, -O-(Ci Cs alkyl)-, -arylene-, -C1-C10 alkylene-arylene-, -arylene-C-i-C-io alkylene-, -C1-C10 alkylene-(C3-Cs carbocyclo)-, -(C3- Cs carbocyclo)-Ci-Cio alkylene-, -C3-C8 heterocyclo-, -C1-C10 alkylene-(C3- Cs heterocyclo)-, -(C3-C8 heterocyclo)-Ci-Cio alkylene-, -C1-C10 alkylene-C(=O)-, -C1- C10 heteroalkylene-C(=O)-, -C3-C8 carbocyclo-C(=O)-, -O-(Ci-Cs alkyl)-C(=O)-, -arylene- C(=O)-, -C1-C10 alkylene-arylene-C(=O)-, -arylene-Ci-Cw alkylene-C(=O)-, -C1- C10 alkylene-(C3-C8carbocyclo)-C(=O)-, -(C3-C8 carbocyclo)-Ci-Cio alkylene-C(=O)-, - C3-C8 heterocyclo-C(=O)-, -C1-C10 alkylene-(C3-C8heterocyclo)-C(=O)-, -(C3- Cs heterocyclo)-Ci-Cio alkylene-C(=O)-, -C1-C10 alkylene-NH-, -C1-C10 heteroalkylene- NH-, -C3-C8 carbocyclo-NH-, -O-(Ci-Cs alkyl)-NH-, -arylene-NH-, -C1-C10 alkylene- arylene-NH-, -arylene-Ci-Cw alkylene-NH-, -C1-C10 alkylene-(C3-Cs carbocyclo)-NH-, - (C3-C8 carbocyclo)-Ci-Cio alkylene-NH-, -Cs-Csheterocyclo-NH-, -C1-C10 alkylene-(C3- Cs heterocyclo)-NH-, -(C3-C8 heterocyclo)-Ci-Cio alkylene-NH-, -Ci-Cwalkylene-S-, -C1- C10 heteroalkylene-S -, -Cs-Cscarbocyclo-S -, -O-(Ci-Cs alkyl)-)-S -, -arylene-S-, -C1-C10 alkylene-arylene-S-, -arylene-Ci-Cw alkylene-S-, -Ci-Cio alkylene-(C3-Cs carbocyclo)-S- , -(C3-C8 carbocyclo)-Ci-Cio alkylene-S-, -C3-C8 heterocyclo-S-, -C1-C10 alkylene-(C3- Cs heterocyclo)-S-, -(C3-C8 heterocyclo)-Ci-Cio alkylene-S-, -C1-C10 alkylene-O-C(=O)-, -C3-C8 carbocyclo-O-C(=O)-, -O-(Ci-Cs alkyl)-O-C(=O)-, -arylene-O-C(=O)-, -C1- C10 alkylene-arylene-O-C(=O)-, -arylene-Ci-Cw alkylene-O-C(=O)-, -C1-C10 alkylene- (C3-C8carbocyclo)-O-C(=O)-,-(C3-C8 carbocyclo)-Ci-Cio alkylene-O-C(=O)-, -C3- Cs heterocyclo-O-C(=O)-, -C1-C10 alkylene-(C3-C8heterocyclo)-O-C(=O)-, and -(C3- Cs heterocyclo)-Ci-Cio alkylene-O-C(=O)-