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Among 9 patients, tumor cells were identified in 7 patients and included for further analysis (Fig

PARP enzyme de novo synthesis of protein-free poly(ADP-ribose)

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Alterations in kidney metabolism lead to abnormal expression of signaling molecules and activation of pathways, inducing oxidative stress-related cellular damage, inflammatory responses, apoptosis, and autophagy irregularities, culminating in renal fibrosis and insufficiency