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The significance of selenoproteins for human health revealed by inborn errors of metabolism

Given the existence of the specific OCTN1 transporter and the selective accumulation in neural and metabolically active tissues, this raises the question of whether the Western decline in mushroom consumption compared to traditional cultures in Asia, where mushrooms have been a staple food for thousands of years may contribute to a chronic undersupply that could correlate with the rise of neurodegenerative disease

Inhibition of Tyr194 phosphorylation elevates the peroxidase activity of Prx1 and makes it an efficient anti-ferroptotic enzyme [143]

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