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Because these actors often favor conflicting surface characteristicsparticularly with respect to roughness and plaque retentionimplant design has historically required compromises

Accordingly, major advances have occurred in understanding the role of these oxidants in physiology and disease, including the nervous, cardiovascular and immune systems, skeletal muscle and metabolic regulation as well as ageing and cancer

Each variant received a TP53 enrichment score wherein a negative TP53 enrichment score is representative of a variant which was depleted in the treatment population as compared to the untreated control population (Fig