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Additionally, dopamine D1 receptor agonism has been found to improve mitochondrial biogenesis and dopaminergic neurogenesis in a 6-OHDA rat model of PD (Mishra et al., 2020)

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2 Vitamin B1 Vitamin B1, or thiamine, is an essential nutrient obtained through dietary sources such as whole-grain products, brown rice, meat, vegetables, and fruits ( Thiamine is integral to the biochemistry of the nervous system, serving primarily as a coenzyme in key enzymatic reactions associated with energy metabolism, particularly the conversion of carbohydrates into usable energy ( In the brain, thiamine is phosphorylated at the cellular level to form its active derivative, thiamine pyrophosphate (TPP) ( Figure 3 )

The percentage of OCFAs content increased about 2-fold for the Yl crc1 strain and significantly increased by 3-fold for the pTEF-RePCT Yl crc1 strains, in the medium without acetate, compared to the medium with acetate (P = 0.003) (Fig