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Short-term secretagogue use producing physiological GH elevation differs substantially from the chronically supraphysiological levels seen in acromegaly, but awareness of these risks remains important

Missing applications frequently means the biological processes triggered by one application may not sustain long enough to produce lasting change

The authors noted that this proliferation-inhibiting effect could have potential utility in anti-tumor applications, though further studies are needed to confirm its relevance in oncology contexts [43]

A phase I clinical trial in patients with refractory solid tumors showed that the ES/paclitaxel combination was well tolerated with a toxicity profile similar to single-agent paclitaxel [116]