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Among the reported abnormalities associated with vitamin B5 deficiency are cerebral and eye defects, digital hemorrhages and edema, interventricular septal defects, anomalies of the aortic arch pattern, hydronephrosis, clubfoot, cleft palate, increased arthritis pain, fatigue, irritability, headaches, gastrointestinal issues, the sensation of weakness, and dermal defects (Gheita et al., 2020

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Surprisingly, 5 m fisetin slightly increased the content of spontaneous melanin and extracellular melanin, fisetin (at 20 m) markedly increased the content and release of melanin in B16F10 cells by up regulating the expression of TYR and MITF, and promoted the melanin synthesis of zebrafish larvae