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Our investigation focuses on the assessment of the association between the Trx system and patient prognosis as a means of evaluating its immunotherapeutic relevance in order to enhance our understanding of the molecular underpinnings of the Trx system in cancer immunity

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Science 343:301305 Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F, McGouran JF, Century H, Persch MG, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobajo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urb S, Clague MJ, Kessler BM, Komander D (2017) Molecular basis of USP7 inhibition by selective small-molecule inhibitors

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