clamitans melanota File:Northern Green Frog (Lithobates melanota) (29760682146).jpg File:Rana clamitans melanota (Northern Green

Various studies have implicated neuroinflammation and cytotoxic factors such as interleukins (ILs), nitric oxide (NO), reactive oxygen species (ROS), and tumor necrosis factor- (TNF-) in the neurodegenerative processes underlying PD (Joshi and Singh 2018)

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[27] The connection between GSTP inhibition of the pro-apoptotic JNK pathway and the isozyme's overexpression in drug-resistant tumor cells may itself account for the tumor cells' ability to escape apoptosis mediated by drugs that are not substrates of GSTP

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