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The intake of high fat diet with different trans fatty acid levels differentially induces oxidative stress and non alcoholic fatty liver disease (NAFLD) in rats

Other mechanisms that regulate the intracellular iron abundance, such as the exportation of iron via various multivesicular bodies and exosomes carrying ferroportin or prominin2-mediated ferritin, can also affect the cellular sensitivity to ferroptosis, as they deplete the cellular iron and accelerate the lipid peroxidation (53) ( Figure 1 )

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Keywords Reactive nitrogen species, reactive oxygen species, endoplasmic reticulum stress, unfolded protein response, drug-induced liver injury Introduction Drug-induced liver injury (DILI) plays an essential role both in the clinic and in drug development [1]