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These physiological processes prevent oral doses from resulting in therapeutic plasma concentrations sufficient for significant antioxidant effects in tissues, and low solubility combined with rapid metabolism reduces the time in which the antioxidant remains in its active form, compromising its efficacy in chronic diseases that require sustained action [57, 58]

S., Anchan N

Hedrich CM, Tsokos GC (2011) Epigenetic mechanisms in systemic lupus erythematosus and other autoimmune diseases

You can probably guess some of the most well-known caffeinated drinks, including: Manufacturers also add caffeine to lots of other products (including some you may not think of), including: Its more common for people to experience a caffeine overdose from supplements mixing highly caffeinated drinks with medication