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Upon exerting its action, melatonin in the brain could be catabolized into kynurenine mtabolites, which represent the other pathway for tryptophan metabolism besides serotonin [149] (Fig

For metabolomics analysis, the culture supernatant was collected, filtered to remove cells, and analyzed using gas chromatography time of flight (GC-TOF) mass spectroscopy for various metabolites, including carbohydrates, sugar phosphates, amino acids, hydroxyl acids, free fatty acids, purines, and pyrimidines

Calcium ions (Ca 2+ ) have been identified as essential regulators of NSC physiology, playing a critical role in their proliferation and differentiation