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The opposite also turns out to be true

Chernick et al., 1989

Khaydukov EVMironovaKESemchishenVAGeneralovaANNechaev AVKhochenkovDAet al

As a further example, corticotropin-releasing factor is secreted from the hypothalamus under stress and, together with neurotensin, can stimulate brain mast cells to release inflammatory and neurotoxic mediators that disrupt the BBB, stimulate microglia, and cause focal inflammation [527, 528]